Ray Peat Audio Archive

ewh-110825-serotonin-and-endotoxin — Ray Peat Clip

This curated audio highlight features Ray Peat speaking in the interview ewh-110825-serotonin-and-endotoxin. The excerpt begins at 28:53 and runs for 58 seconds.

Now, what are the hormones that serotonin kind of synthesizes with? Obviously, it's not just by itself release. You talked about histamine. What is its correlation with estrogen? Estrogen activates the enzyme that turns tryptophan to serotonin, the rate limiting tryptophan hydroxylase is activated by estrogen and inhibited by progesterone. And that's the route into the serotonin and the route out of serotonin is, for example, the monoamino oxidase type A happens to be inhibited by estrogen so it doesn't break down serotonin and it's activated by progesterone so it breaks down serotonin.