Ray Peat Audio Archive

kmud-211217-the-hormones-behind-inflammation — Ray Peat Clip

This curated audio highlight features Ray Peat speaking in the interview kmud-211217-the-hormones-behind-inflammation. The excerpt begins at 23:18 and runs for 2 minutes.

It's progesterone rising one of the natural functions of estrogen is to evoke the progesterone receptor making the cells open to being turned off by progesterone. So it's sort of an automatic process the estrogen should excite and inflame the tissue but immediately turn the tissue towards looking for relief from progesterone by increasing the progesterone receptor and if you can produce progesterone partly acting through the progesterone receptor partly outside that way of influencing, one of the first effects of progesterone is to knock out the estrogen roughly ten different ways progesterone knocks out those pro-inflammatory effects of estrogen turning off the production of estrogen knocking out the estrogen receptor so the tissue is less sensitive to estrogen and changing the metabolism and so on and exactly what happens to make pregnancy possible is what happens every time you have a little injury that evokes the estrogen activated start of the healing or immune process that should increase the cells ability to receive and be saved or matured by progesterone produced elsewhere in the organism.