Ray Peat Audio Archive

#35： CO2, Ketosis, and Mitochondria ｜ PUFA, Sugar, Ir… — Ray Peat Clip

This curated audio highlight features Ray Peat speaking in the interview #35： CO2, Ketosis, and Mitochondria ｜ PUFA, Sugar, Iron, and AGEs ｜ Progesterone and Cell Stability [utZ8DVDUWCbu]. The excerpt begins at 40:40 and runs for 1 minute 50 seconds.

I have a question related to progesterone and pregnenolone. In some of the older studies, especially the ones that Celia did, he showed that giving people pregnenolone decreases their excretion of 17 kerosteroids, which Celia thought means that pregnenolone is giving the adrenals a break, but without the negative effects of, let's say, taking cortisol directly. Would you say that pregnenolone probably fills in for some of the roles of cortisol? Yeah, an experiment in rats around 1950 gave, with a stomach tube, they gave them, I think, was a 10 gram dose of pregnenolone filling their stomachs with it, and they had measured their cortisol before the experiment, and a certain proportion of them had above normal level of cortisol, showing that they were having to respond that way to stress of some sort. But all of them having received this gigantic dose of pregnenolone, all of them had normal levels of cortisol after that, so it bypassed the need to produce cortisol. And people tend to think of a mass action effect that if you eat a lot of pregnenolone, won't you get increased levels of the product, but it's