#82： What's More Toxic： PUFA or Endotoxin？ ｜ Euphoria ｜ Addiction ｜ Meaningful Work ｜ Current Events [U2f0WOaTmu4] Recording 00:31:55.000 Copy and pregnenolone. And that was how I found out that pregnenolone can help people withdraw pretty quickly from the opiates. Quick question about pregnenolone. Why do you think no pharma company so far has tried to develop pregnenolone or at least use it or even in medicine as a sort of like the mother of all hormone replacement therapies? I mean if it's the precursor for all of them, wouldn't something like a transdermal cream or a suppository or some other kind of a product that basically contains pregnenolone be able to replace all of these other HRTs that are trying to sell to the public?
ewh-110929-cholesterol-and-saturated-fats Recording 00:45:48.100 Copy pound of progesterone all at once, or pregnenolone rather. So pregnenolone alone, could nutrition philosophies do enough if you're making the conversion to raise pregnenolone to help with brain chemistry, skin tone, and overall stress reduction? Or do you recommend possibly using a powder of pregnenolone to actually help balance that and lower cholesterol? Yeah, it depends on how far the system has deteriorated. Many years ago, some Russians found just with isolated mitochondria that giving them pregnenolone would structurally restore damaged mitochondria and allow them to begin producing more pregnenolone. And that's similar to what people saw with isolated progesterone on slices of adrenal gland.
Generative Energy: Restoring the Wholeness of Life Book p. 90 Copy I think DHEA gives similar results, and (like progesterone) is more easily absorbed than pregnenolone. Both progesterone and pregnenolone seem to improve the efficiency of blood circulation. I have seen grey-skinned depressed people turn pink and start smiling shortly after taking pregnenolone. About 1950, pregnenolone was tested on several people with exophthalmia from Graves' disease, and it was reported that their eyes quickly receded toward a more normal position in their sockets. Having read this, I mentioned it to a desperate woman with horribly bulging eyes. Her left eyeball was about 50% exposed, and the other one was less extreme, but still seriously protuberant.
yohaf-961112-thyroid-progesterone-and-diet Recording 00:23:40.700 Copy animals or people who are given pregnenolone, the only hormonal consequence is that if their cortisone is elevated, pregnenolone brings it down to normal. That's because the elevation of cortisol is connected through mechanisms in the brain circuitry. High cortisol is a symptom of a pregnenolone deficiency and once you get your cortisone down by having enough pregnenolone, then any amount of pregnenolone you take has no hormonal action whatsoever but you need to be saturated otherwise you are going to resort to cortisone and cortisone is the basic thing that ages the skin, the brain cells, the bones.
sourcenutritional-120512-brain-and-tissue-2 Recording 00:09:32.600 Copy and you wanted to use pregnenolone and progesterone, would that be fine and dandy? Is there any precaution that we should take into consideration in using pregnenolone for kids? Well, pregnenolone is even easier to use. It doesn't have any known so-called hormonal effects in itself. It does seem to help the body handle the tone of connective tissue and sphincter muscle and such, those aren't recognized as hormone effects. So pregnenolone isn't considered a hormone, but it's a precursor, like a nutrient for any tissue that does use the steroid hormones. So it just helps balance the things that the body is naturally trying to do.
Progesterone in Orthomolecular Medicine Book p. 21 Copy Pregnenolone, taken orally, does nothing noticeable to a healthy animal or person, but if the stress-related hormones are elevated, they return to normal when pregnenolone is taken. The brain contains much more pregnenolone, DHEA, and progesterone than do other organs or the blood, and these levels decrease progressively with age. Older people are more likely to feel an effect from pregnenolone, than are young people. A tenth of a gram is a reasonable first dose, though some people seem to need as much as 1 gram per day, possibly because of poor absorption. (The amount produced daily in a healthy young adult is roughly 30 mg.)
kmud-130315-palpitations-and-cardiac-events Recording 00:54:33.600 Copy Pregnenolone. And you can find it at-- where are you calling from, caller? Just outside of Redway, a little bit. Okay, yeah, so at Chautauqua they'll have pregnenolone. Pregnenolone. Pregnenolone. And it's a precursor for all of our steroid hormones. Oh, okay. Okay. All right, great. Okay, just to make sure that you heard the name, it's Preg, as in pregnant, Pregnenolone. Preg, oh, okay. Yeah, P-R-E-G-N-E-N-O-L-O-N-E. Okay. But it's a-- it's found in men and women. It's made from cholesterol from our liver, so it's a very common hormone in everybody.
kmud-180615-positive-thinking-sleep-repair Recording 00:46:46.200 Copy somebody who was uh wondering about using pregnenolone and i think because of bad publicity or whatever else you know that they've been worried about progesterone and pregnenolone they've kind of put them in the same basket um they've read about this subject called pregnenolone steel where people with worn out adrenals apparently uh get this issue where pregnenolone is stolen and converted into cortisol is that even possible oh whenever you are making cortisol you're making it from a pregnenolone ultimately and uh it you should have a huge excess of pregnenolone and progesterone and only make small amounts
05.18.20 Does Carona Virus exist as told to us, Ray Peat, May 18 2020 [823303075] Recording 01:06:11.900 Copy same as testosterone and pregnenolone, the stabilizing steroids that protect against cortisol. But I think it's safer to use pregnenolone if you can find a safe and pure form. Pregnenolone. Oh, more emails here. Got lots of them. Patrick Timpani along with Dr. Ray Peat. Sorry, my little mouse is not cooperating. Oh, here you go. What does it mean from Stefan, what does it mean when a woman bleeds during ovulation? Is it a progesterone issue? To some extent, yeah. The surge of estrogen, its effect is to break down the lining of the uterus and that's opposed by progesterone.
#82： What's More Toxic： PUFA or Endotoxin？ ｜ Euphoria ｜ Addiction ｜ Meaningful Work ｜ Current Events [U2f0WOaTmu4] Recording 00:33:37.500 Copy And it's hormonally more powerful than pregnenolone, but pregnenolone has the same position in the system. When you take other hormones, the body's production of that hormone decreases. But in the case of progesterone and pregnenolone, those substances support the body's production of more up to their ability to make more. So if you're deficient in progesterone, sometimes a single dose or two can activate your body to return to normal production if you have the thyroid, vitamin A, and cholesterol needed. And to a degree, the same situation with pregnenolone.
rainmaking-140602-energy-protective-materials Recording 01:17:43.300 Copy are the factors we need mostly for producing pregnenolone from cholesterol. So if you're low in cholesterol or thyroid or vitamin A, you're necessarily going to be deficient in pregnenolone, and pregnenolone is the immediate precursor to progesterone and DHEA. Progesterone is the precursor to cortisol. DHEA is the precursor to testosterone and other androgens and estrogen. If you are deficient in the precursors, the body will still have the ability to make a normal or even increased amount of the end hormones, which in the extreme situation tend to be cortisol and estrogen.
yohaf-961112-thyroid-progesterone-and-diet Recording 00:38:22.800 Copy safety like with pregnenolone, thyroid, progesterone first and then try as your last resort, try the one that tends to kill you sooner. That makes sense, so thyroid and pregnenolone first, that makes sense. You've had some success treating Graves' disease with pregnenolone. I mean they're irradiating people's thyroids for Graves. Yeah, there's published stuff using what I consider mild doses of pregnenolone. All of their people, the eyes receded and in my few experiences the eyes just sort of were sucked back into the head.
From PMS to Menopause: Female Hormones in Context Book p. 73 Copy Pregnenolone, taken orally, does nothing noticeable to a healthy animal or person, but if the stress-related hormones are elevated, they return to normal when pregnenolone is taken. The brain contains much more pregnenolone, DHEA, and progesterone than do other organs or the blood, and these levels decrease progressively with age. Older people are more likely to feel an effect from pregnenolone, than are young people. A tenth of a gram is a reasonable first dose, though some people seem to need as much as 1 gram per day, possibly because of poor absorption. (The amount produced daily in a healthy young adult is roughly 30 mg.)
#35： CO2, Ketosis, and Mitochondria ｜ PUFA, Sugar, Iron, and AGEs ｜ Progesterone and Cell Stability [utZ8DVDUWCbu] Recording 00:40:40.600 Copy I have a question related to progesterone and pregnenolone. In some of the older studies, especially the ones that Celia did, he showed that giving people pregnenolone decreases their excretion of 17 kerosteroids, which Celia thought means that pregnenolone is giving the adrenals a break, but without the negative effects of, let's say, taking cortisol directly. Would you say that pregnenolone probably fills in for some of the roles of cortisol? Yeah, an experiment in rats around 1950 gave, with a stomach tube, they gave them, I think, was a 10 gram dose of pregnenolone filling their stomachs with it,
kmud-110715-hair-loss-inflammation-osteoporosis Recording 00:38:19.600 Copy And sophametol, that's similar to pregnenolone, but it's not -- so, I mean, that would help with -- men notice an increase in their testosterone, but I think it's just because it's helping increase pregnenolone. Yeah, and pregnenolone blocks the stress hormones, primarily turning off excess cortisol production. But when you block the stress reaction, you also prevent overproduction of estrogens. So, it can leave your own testosterone unopposed. Do you have any experience with yoghim bean, perhaps, as a -- No, and I don't know much about it. Just I've read many articles, but I don't really understand it.
wp-121123-foundational-hormones Recording 00:17:32.600 Copy I think if that is what we do, then we probably need a boost of pregnenolone after the age of 40, yet most people don't know, probably because it can't be patented. Is that correct? Yes, pregnenolone is the first hormone produced from cholesterol when our thyroid function is adequate. And I'd just like to emphasize it is made from the LDL, which is classified as the bad cholesterol. Is that correct? Yes. And cholesterol has been injected into animals, and when they're being trained, they become more intelligent and learn more quickly when their cholesterol is higher.
03.15.21 Peat Ray March [1009402927] Recording 01:24:43.000 Copy such a good conversion of cholesterol to pregnenolone, and of pregnenolone to DHEA and progesterone, that you don't have to resort to stress factors such as cortisol, aldosterone, and estrogen. Those are opposed by pregnenolone, DHEA, and progesterone, and thyroid is the main factor for converting your cholesterol to those. So if your cholesterol is low, besides tending to your thyroid, you have to figure out how to get your cholesterol up to normal. But usually, people with high cholesterol, when they supplement the right amount of thyroid, the cholesterol comes down exactly as the thyroid takes effect.
#38： In Defense of Mexican Coke ｜ The Authoritarian Metabolism ｜ Symbols of an Alien Sky ｜ Astrology [LKsogI7Hu9E] Recording 02:02:28.700 Copy I got from them seem to indicate that you don't think it's ever the actual pregnenolone that's causing this. It's some kind of a contamination that's in the pregnenolone. Do you have any specific things in mind in terms of contaminants that may cause such reactions, considering that the pregnenolone is at least – has been shown to be of such high purity? Yeah, that one part per thousand or less, if it's something very active like an estrogenic fragment of a steroid, it takes only a few micrograms of an estrogenic substance to cause symptoms like sore breasts or uterine spasms or cramps.
06.21.21 Pear Ray [1073174857] Recording 01:36:04.600 Copy So you have to test any particular brand of pregnenolone that you get. Watch out for any hormonal symptom at all. It shouldn't be associated with pregnenolone. Nothing but an anti-stress effect should result from pregnenolone. No uterine or breast sensations, no changes of whisker growth or such. Progesterone is mainly produced by the biggest, oldest chemical companies. And so if you get a good brand of it, you know that it is unlikely to be contaminated. Just be careful with what you're using here. And otherwise, the effect of progesterone is immediate as a quieting anti-stress effect.
rainmaking-110704-life-supporting-substances Recording 00:36:29.600 Copy "Could it be that that E had retained some of the pregnenolone that I had stirred into it?" And so I got up and took just a pinch of plain pregnenolone powder, and in about 30 or 40 minutes, all of my symptoms had disappeared. That was 1984, and since then, the symptoms have never returned. For several years, I took--every 10 days, I would take a good fat pinch of pregnenolone, maybe 300 milligrams, and one dose of it, for me, would last 10 days before the symptoms would return.
